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Tadalafil Cialis Male Enhancement Powder

Cialis powder is available as a monohydrochloride salt.
Tadalafil is white crystalline powder and practically insoluble in water and slightly soluble in ethanol.
The water solubility of Tadalafil is 0.25 mg/mL and melting point is 301°C -302°C.
Tadalafil is a PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under the name Cialis .Cialis tablets, in 2.5 mg, 5 mg, 10 mg, and 20 mg doses, are yellow, film-coated, and almond-shaped. On November 21, 2003 the FDA approved tadalafil (as Cialis) for sale in the United States as the third ED prescription drug pill (after sildenafil (Viagra) and vardenafil (Levitra)). Like sildenafil and vardenafil, tadalafil is recommended as an 'as needed' medication. Cialis is also offered as a once-daily medication.

How Tadalafil (Cialis) works (mode of action)?
The mode of action of Tadalafil is same as that of other drugs used for the treatment of erectile dysfunction such as Sildenafil and Vardenafil.
Tadalafil has a longer half-life (17.5 hours) in comparison with other erectile dysfunction medications such as Viagra and Levitra (4-5 hours). This longer half-life results in a longer duration of action that provides Tadalafil a nickname of the “weekend pill.
During sexual stimulation, nitric oxide (NO) is released in the corpus cavernosum (a pair of sponge-like areas of erectile tissue, which hold blood in the penis during an erection) located around the penis.
The nitric oxide in turn activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP). The increased level of cGMP causes relaxation of penile arteries and corpus cavernosal smooth muscles, resulting in increased inflow of blood and penile erection.
Tadalafil selectively brings about the inhibition of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type (PDE5), which is responsible for degradation of cGMP (cyclic guanosine monophosphate) in the corpus cavernosum of the penis.
The inhibition of PDE5 by Tadalafil causes increased and constantly maintained levels of cGMP under normal sexual stimulation in the corpus cavernosum, which leads to better penile erections.
The inhibition of phosphodiesterase type 5 (PDE5) by Tadalafil enhances erectile function by increasing the amount of cGMP.
However, the drug will not work in the absence of sexual stimulation and activation of the NO/cGMP system.