Description of Gonadorelin Acetate

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Description of Gonadorelin Acetate



Item Name:Gonadorelin Acetate powder,Gonadorelin powder
Molecular Formula: C55H75N17O13
CAS No.: 71447-49-9
Sequence:
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
Description of Gonadorelin Acetate:
Appearance: White powder
Specific Optical Rotation [a]eq \o(\s\up 6
(20),\s\do 2( D))20 D(c=1,1% HAc): -55.0~-65.0°
Water Content(Karl Fischer): ≤8.0%
Acetate Content(by HPLC): ≤10.0%
Amino Acid Composition: ±10% of theoretical
Purity (by HPLC): ≥98.0%
Single Impurity(by HPLC): ≤1.0%
Peptide Content(by %N): ≥80%
Assay(By Anhydrous, Acetic Acid-free ): 95.0~105.0%
Becterial Endotoxins: ≤5EU/mg
Gonadotropin-releasing hormone (GnRH) is considered a neurohormone, a hormone produced in a specific neural cell and released at its neural terminal. A key area for production of GNRH is the preoptic area of the hypothalamus, which contains most of the GnRH-secreting neurons. GnRH neurons originate in the nose and migrate into the brain, where they are scattered throughout the medial septum and hypothalamus and connected by very long >1-millimeter-long dendrites. These bundle together so they receive shared synaptic input, a process that allows them to synchronize their GnRH release.