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About NSI-189, a New Experimental Nootropic

About NSI-189, a New Experimental Nootropic

Modern antidepressants focus on the monoamine neurotransmitter system (serotonin, dopamine, noradrenaline, and even histamine and melatonin), but only two-thirds of the patients treated for major depression achieve clinically significant improvements. Available antidepressants have side effects that could negatively affect treatment. The largest potential for advances in treatment may require creating medications that use different mechanisms, which is what NSI-189 attempts to do.

Disclaimer: By writing this post, we are not recommending this drug. Some of our readers who were already taking the drug requested that we commission a post on it, and we are simply providing information that is available in the clinical and scientific literature.NSi-189 powder

What is NSI-189?

NSI-189 is an experimental antidepressant. Neuralstem, Inc. is currently testing it for use in major depression, in addition to treating cognitive impairments, and brain degeneration. It may induce specific brain regeneration [1].

NSI-189 is most likely selective only to two nervous system controlling regions in the brain (hippocampus, subventricular zone) [1].
According to the developer, NSI-189 is still currently in preclinical trials for [3]:

Cognitive impairment and radiation-induced cognitive impairments
Diabetes-related weakness, and numbness and pain from nerve damage
Ischemic (lack of blood flow or oxygen to the brain) stroke associated
Angelman syndrome (a genetic disorder causing developmental disabilities and nerve-related symptoms)
NSI is experimental and no one knows the long-term side effects of the drug. The clinical trials being done were performed by the drug company selling it, so suspicion is always warranted until there are large-scale independent clinical trials.

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