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Guidelines for Treatment of Chronic Hepatitis B(1) .. Persons needing immunosuppressive therapy, including chemotherapy, immunosuppression related to organ transplantation, and reactivation if they have preexisting HBV and should. 23 Mar 2017 tivation in patients requiring immunosuppression or chemother- apy. Keywords: Hepatitis B; EASL guidelines; Treatment; Interferon; Entecavir;. Tenofovir; TAF; HBsAg; Hepatocellular carcinoma; HBV DNA; HBV reactivation;. 17 Apr 2017 Hepatitis B virus (HBV) infection remains a global public health problem with of HBV reactivation in patients requiring immunosuppression or 13 Jun 2016 In the absence of antiviral prophylaxis, HBV reactivation has been observed in some patients as late as 6-12 months after cessation of chemotherapy in both HBsAg positive and HBsAg negative/anti-HBc positive patients, and also when the antiviral prophylaxis has been curtailed to just 2 months post-completion of 24 Apr 2015 Dr David Johnson reviews the highlights, but advises all clinicians who treat patients with immunosuppressive therapy to read the guidelinesAmerican Gastroenterological Association Institute Guideline on the Prevention and Treatment of Hepatitis B Virus Reactivation During Immunosuppressive 15 May 2017 inactive hepatitis B may occur in patients receiving im- munosuppressive therapy. evidence and expert guidelines in the literature to provide. Those who have a moderate risk of reactivation but are HBsAg negative/anti-HBc positive (HBV infection in the past), anti-HBV prophylaxis should be considered or they also could be monitored for serum ALT and HBsAg levels every 3 months until 6 months after the last dose of immunosuppressive therapy. 18 Dec 2017 EASL clinical practice guidelines: Management of chronic hepatitis B Preventing hepatitis B reactivation due to immunosuppressive drug hepatitis B reactivation due to immunosuppressive ther- apy is included (Figure . Study of Liver (EASL) guideline divides chronic HBV infection into five phases.