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The 5- HT1A is a member of the family of 5- HT receptors , which are activated by the neurotransmitter serotonin. Found in both the central and peripheral nervous systems, 5- HT receptors trigger several intracellular cascades of chemical messages to produce an excitatory or inhibitory response, depending on the chemical context of the message. The CBDA [cannabidiolic acid], raw unheated version of the CBD is present in the Cannabis plant, also it has a strong affinity for the 5- HT1A (even more than CBD ). Both CBD and CBDA trigger an inhibitory response that slows down the 5- HT1A signaling . In comparison, LSD , mescaline, magic mushrooms and several other hallucinogenic drugs activate the 5- HT2A receptor , which produces an excitatory response.


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