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Cannabidiol ( CBD ), a non-psychoactive component of the marijuana plant, has generated significant interest among scientists and physicians in recent years, but the way in which the CBD exerts its therapeutic impact at a molecular level remains a research topic for scientists. Cannabidiol is a pleiotropic drug in the sense that it produces many effects through multiple molecular pathways. Although CBD has little binding affinity for either of the two cannabinoid receptors ( CB1and CB2 ), CBD activates several non-cannabinoid receptors and ion channels. It also acts through several receptor-independent channels-for example, by delaying the "reuptake" of endogenous neurotransmitters (such as anandamide and adenosine) and by increasing or inhibiting the binding action of certain receptors coupled to type G proteins.


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