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Bio-Spira® saltwater aquarium bacteria helps reduce dangerous levels of nitrite BIO-Spira can also be used after a water change, when adding new fish or In just minutes after adding BIO-Spira to your saltwater aquarium, you can introduce your fish without exposure to dangerous levels of Directions for Use Nov 10, 2013 Use the bio spira but wait till you test 0 ammonia. You can add household ammonia. Just make sure it is pure and no livestock in tank. I did this Feb 21, 2006 I know the Bio-Spira claims that you can add it at the same time as Just follow the directions on the package of Bio Spira and you will be fine. I was thinking of adding a full bottle of bio spira at the end of the all the We talk in our thread about using the manual work portion of a huge Sep 1, 2014 Directions. SHAKE WELL For new aquariums: Add entire pouch to cycle up Ideal to use when adding new fish, filter maintenance and monthly water changes.BIO-Spira can also be used in established saltwater aquariums after a water change, when adding new fish, or after medicating. For best results in an established aquarium, be sure to: Turn OFF UV sterilizers and protein skimmers for 48 hours. Remove all medications with a water changes or activated carbon. Items 1 - 12 of 36 In just minutes after adding BIO-Spira to your saltwater aquarium, you can introduce your fish without exposure to dangerous levels of ammonia Instant Ocean Bio-Spira Start Up Nitrifying Bacteria Aquarium Additive, 3.38 fl. oz. By: Instant Ocean 8 Months, 10 Months, 12 Months. Add to Cart Directions