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Research showed that a 'water only' starvation diet worked because substances called ketone bodies, produced as a byproduct of fat burned for energy, were released into the bloodstream by the liver. These acted in the brain to combat the abnormal nerve impulses blamed for epilepsy. Later studies found that a low-carb, high-fat diet could do the same job and the ketogenic diet was born. After falling out of favour for a few decades, when medicines for epilepsy improved, the diet had a resurgence in the 1990s thanks to high-profile doctors in the US, and is still used today as a first-line treatment for some neurological conditions.

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