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But, you may still opt for an over-the-counter (OTC) nail fungus treatment once you learn what products work best. Dr. Trepal advises that while there is anecdotal evidence that OTC treatments work, there aren't any definitive scientific, randomized studies that clearly show their efficacy. Starting treatment at the onset of a fungus infection gives folks the best chance at removing the infection for good. As Dr. Trepal explains to me, “The only method that definitely gets rid of [nail fungus] in most if not all patients is to permanently remove the toenail.”
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